Preheat your oven to 350ºF.

In a small bowl, whisk together the egg, milk, and Worcestershire sauce.

In a separate small bowl, stir together the breadcrumbs, Italian seasoning, garlic powder, salt, and black pepper.

Mince the onion finely.

In a large bowl, add the ground beef, egg mixture, breadcrumbs, and minced onion. Mix until evenly combined.

Shape the meat mixture into a loaf in a rimmed baking dish.

In a separate bowl, combine the glaze ingredients: ketchup, brown sugar, Worcestershire sauce, and mustard.

Spread the glaze over the meatloaf.

Bake in the preheated oven for 50-55 minutes or until the internal temperature reaches 165ºF.

Allow the meatloaf to rest for 5-10 minutes before slicing and serving.