Preheat your oven to 400 degrees F (204 degrees C). Line an extra-large baking sheet or two jelly roll pans with foil or parchment paper for easy cleanup.
In a large bowl, toss the Brussels sprouts with olive oil, garlic powder, salt, and pepper. Ensure they are well-coated for maximum flavor.
Spread the Brussels sprouts in a single layer on the prepared pan(s), making sure each one touches the pan to encourage even browning.
Roast the Brussels sprouts for about 25-35 minutes, tossing them halfway through. They should be browned and slightly charred for the best taste.
If desired, place the tray under the broiler for an additional 2-3 minutes to make them even more browned and crispy.
Notes
Ensure even sizing for uniform cooking.
Consider adding a splash of balsamic vinegar or lemon juice for extra flavor.